Modeling microfluidics in computer-aided design (CAD) can be intimidating, but with some practice, becomes quick and easy. Below is a video on how we model a microfluidic droplet generator for CNC machining on acrylic (PMMA).

In the video, the microfluidic droplet generator is designed using Fusion 360 as it has a 'free' non-commercial license available to the general public. Fusion 360 also has computer-aided manufacturing (CAM) in its 'free' license, which is needed to set up the CNC programs. While SolidWorks may be more popular, its CAM can be expensive. Fusion 360 was just as easy to learn and use as SolidWorks.

P.S. to rotate a model in Fusion 360 use "Shift + Middle Mouse Button"

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The video provides a general overview on making a droplet generator with easy-to-follow steps such as modeling the cross junction and best practices for microchannel construction using the 'extrude thin' function.

The 3D model is not DFM-friendly (design for manufacturing), which typically includes a draft on the entire part to help with ejection from the mold.