Understanding Dead Volume, Swept Volume, and Void Volume in Microfluidics: Concepts and Calculator
Published by Ehsan Shamloo on Dec 22nd 2024
Swept Volume Calculator
In microfluidics, dead volume refers to the space in a system where fluid stagnates and is not actively transported or utilized, often leading to inefficiencies or contamination. Swept volume, on the other hand, is the actively utilized volume through which fluid flows during operation, critical for ensuring efficient reagent usage and process reliability. Void volume generally denotes the empty space within a system or between packed materials, such as in a column, that can affect fluid flow and system dynamics. Understanding and minimizing dead volume while optimizing swept and void volumes is crucial for achieving precise control and efficient performance in microfluidic applications.
The liquid volume inside a tube (with circular cross section) is determined by the volume of the cylinder formed by the tube's internal diameter (ID) and its length.
let diameterInMm = true; let lengthInMm = true;
function toggleUnit(field, unit) { if (field === 'diameter') { diameterInMm = (unit === 'mm'); } else if (field === 'length') { lengthInMm = (unit === 'mm'); } }
function calculateVolume() { let diameter = parseFloat(document.getElementById('diameter').value); let length = parseFloat(document.getElementById('length').value);
if (isNaN(diameter) || isNaN(length) || diameter <= 0 || length <= 0) { alert('Please enter valid positive numbers for diameter and length.'); return; }
if (!diameterInMm) diameter *= 25.4; if (!lengthInMm) length *= 25.4;
const radius = diameter / 2; const volumeMm3 = Math.PI * Math.pow(radius, 2) * length; const volumeIn3 = volumeMm3 / 16387.064;
document.getElementById('result').innerHTML = `
Liquid Volume:
${volumeMm3.toPrecision(3)} cubic millimeters (mm³)
${volumeIn3.toPrecision(3)} cubic inches (in³)
`;
}