Description
Our Degasser is the smallest and most affordable on the market, useful for removing dissolved gasses and can be equipped with up to six degasser cartridges made from Teflon AF tubing (PTFE) or teflon membranes.
Also offered as a kit without the housing for your own OEM instrument integration. Different cartridge volumes available.
Dissolved gasses in mobile phases cause baseline drift, false optical peaks, and pump cavitation (air lock) in liquid chromatography. As liquid flows through the highly permeable Teflon tubing housed inside a vacuum chamber, the controlled pressure differential extracts dissolved gases across the membrane wall without altering solvent composition.
Equipped with high-permeability fluoropolymer tubing membranes (Teflon AF™) and a continuous-vacuum micro-pump, this unit ensures smooth flow rates, stable detector baselines, and reproducible retention times across HPLC, UHPLC, GPC, and LC-MS applications.
Key Benefits & Technical Advantages
- Eliminate Baseline Noise & Spurious Peaks: Prevents outgassing during solvent mixing, stabilizing UV/Vis, refractive index (RI), and mass spectrometry detectors.
- Low Internal Hold-Up Volume: Optimized flow channels minimize solvent turnover times, reducing flush volume during mobile phase transitions.
- Chemically Inert Wetted Path: Built with Teflon™ AF PTFE tubing and PEEK fittings, providing universal compatibility with aggressive organic solvents, aqueous buffers, and acidic mobile phases.
- Compact OEM Integration: Available as a standalone benchtop module or as a drop-in OEM kit for system integrators.
Technical Specifications
| Parameter | Specification |
|---|---|
| Degassing Mechanism | Continuous inline vacuum membrane separation |
| Membrane Material | Fluoropolymer (Teflon™ AF PTFE) |
| Number of Channels | Up to 6 independent channels |
| Internal Volume (per channel) | 280 μL – 480 μL (low-volume option available) |
| Max Flow Rate | Up to 5 mL/min per channel (analytical/semiprep options) |
| Solvent Compatibility | Acetonitrile, Methanol, THF, Water, Buffer solutions (pH 1–14) |
| Operating Pressure Range | Vacuum pressure controlled at constant vacuum |
| Wetted Materials | PEEK, Teflon AF |
| Dimensions & Power | 105 mm × 50 mm × 165 mm | 24 V DC / 100–240 V AC supply |
Applications
- HPLC & UHPLC Systems: Maintains stable mobile phase composition during gradient runs.
- LC-MS Systems: Reduces dissolved oxygen interference and ion suppression artifacts.
- Ion & Size Exclusion Chromatography (SEC): Prevents degassing during high-salt buffer mixing.
- Microfluidic & Precision Fluidics: Guarantees pulse-free continuous liquid flow in automated diagnostic platforms.
Frequently Asked Questions (FAQ)
Why is inline vacuum degassing better than helium sparging or ultrasonic baths?
Ultrasonic degassing and helium sparging are manual, batch processes. Solvents quickly re-absorb atmospheric gases once resting on the bench. An inline vacuum degasser continuously removes gases in real time, ensuring consistent dissolved gas concentration throughout long analytical runs.
How often do the degassing membranes need replacement?
Under standard laboratory conditions with clean, filtered solvents, the degassing channels operate for over 5,000 continuous hours without degradation. Annual inspection of vacuum pump seals and filter frits is recommended for optimal longevity.
